Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

May 6, 2025

Primary Completion Date

April 30, 2028

Study Completion Date

May 31, 2028

Conditions
Gastric NeoplasmsEsophageal CancerLiver CancerLiver MetastasisMSS-CRCMSSGastric AdenocarcinomaPeritoneal CancerPeritoneal CarcinomaPeritoneal MetastasesMSI-HGastric Cancer
Interventions
BIOLOGICAL

vvDD-hIL-2-RG-1

"A single dose of the investigational agent will be injected intratumorally at one of the following three dose levels.~Level 1: 3 x 108 p.f.u. Level 2: 1 x 109 p.f.u. Level 3: 3 x 109 p.f.u. p.f.u = Plaque-forming unit(s)~Dose will be escalated in cohorts of 3, according to a standard 3+3 design."

Trial Locations (1)

15224

RECRUITING

AHN West Penn Hospital, Pittsburgh

All Listed Sponsors
lead

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

OTHER

NCT07001592 - Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors | Biotech Hunter | Biotech Hunter