NCT07001085 - ctDNA Monitoring in Patients With HCC and mCRC | Biotech Hunter

Enrollment

300

Participants

Timeline

Start Date

January 1, 2025

Primary Completion Date

February 1, 2027

Study Completion Date

April 30, 2028

Conditions

HCC - Hepatocellular CarcinomaColorectal Cancer Metastatic

Interventions

DIAGNOSTIC_TEST

Tumor Tissue Collection and NGS

Tumor tissue is collected during surgery and used for DNA extraction. Next-Generation Sequencing (NGS) is performed to identify oncogenic mutations.

OTHER

Blood Collection for Plasma ctDNA

Blood is collected at three time points: one day before surgery, one month, and six months after surgery. Plasma is separated and used for further molecular analysis or storage.

DIAGNOSTIC_TEST

ctDNA Mutation Analysis via ddPCR

Circulating tumor DNA (ctDNA) is isolated from plasma samples. Mutations previously identified by NGS are quantitatively analyzed using droplet digital PCR (ddPCR).

Trial Locations (1)

02-091

RECRUITING

Medical University of Warsaw, Warsaw