A Study of Apatinib Combined With Letrozole With or Without Fluzoparib in Estrogen Receptor-Positive, Platinum-Sensitive Recurrent Ovarian Cancer Previously Treated With First-Line PARP Inhibitor

NANot yet recruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

October 1, 2027

Study Completion Date

October 1, 2028

Conditions
Ovarian Cancer
Interventions
DRUG

Cohort 1 (triple-drug group)

"Apatinib: 250 mg orally once daily, with a 28-day treatment cycle. Fluzoparib: 100 mg orally twice daily, with a 4-week continuous treatment cycle.~Letrozole: 2.5 mg orally once daily, with a 4-week continuous treatment cycle. Treatment continued until disease progression, intolerable toxicity, or other protocol-specified reasons occurred."

DRUG

Cohort 2 (dual-drug group)

Apatinib: 250 mg orally once daily, with a 28-day treatment cycle. Letrozole: 2.5 mg orally once daily, with a 4-week continuous treatment cycle. Treatment continued until disease progression, intolerable toxicity, or other protocol-specified reasons occurred.

All Listed Sponsors
lead

Peking Union Medical College Hospital

OTHER