DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

November 19, 2024

Primary Completion Date

October 31, 2029

Study Completion Date

October 31, 2029

Conditions
Solid TumourHaematological MalignancyMalignant NeoplasmNeoplasms by Histologic TypeNeoplasms by SiteCancerMalignancyGliomaNeuroblastomaGastric CancerSoft Tissue Sarcoma
Interventions
DRUG

Capmatinib

Patients will be administered capmatinib orally at a daily dose of 800 mg consisting of 400 mg (two 200mg tablets) twice daily. Each cycle of treatment will consist of 28 days and patients may continue on treatment until disease progression without clinical benefit, unacceptable toxicity or withdrawal of consent.

Trial Locations (16)

BT9 7AB

NOT_YET_RECRUITING

Belfast City Hospital, Belfast

B15 2TT

RECRUITING

University Hospital Birmingham, Birmingham

BS2 8ED

RECRUITING

Bristol Haematology and Oncology Centre, Bristol

CF14 2TL

RECRUITING

Velindre Cancer Centre, Cardiff

EH4 2XU

RECRUITING

Western General Hospital, Edinburgh

G12 OYN

RECRUITING

The Beatson Hospital, Glasgow

LE1 5WW

RECRUITING

Leicester Royal Infirmary, Leicester

NW1 2BU

RECRUITING

University College London Hospital, London

SE1 9RT

RECRUITING

Guy's Hospital, London

M20 4BX

RECRUITING

The Christie Hospital, Manchester

CH63 4JY

RECRUITING

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

NE7 7DN

RECRUITING

Freeman Hospital, Newcastle

OX3 7LE

NOT_YET_RECRUITING

Churchill Hospital, Oxford

S10 2SJ

RECRUITING

Western Park Hospital, Sheffield

SO16 6YD

RECRUITING

Southampton General Hospital, Southampton

SM2 5PT

RECRUITING

Royal Marsden Hospital, Sutton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

University of Birmingham

OTHER

collaborator

Royal Marsden NHS Foundation Trust

OTHER

collaborator

Novartis Pharmaceuticals

INDUSTRY

collaborator

University of Manchester

OTHER

lead

Cancer Research UK

OTHER