CAR19BCMA CAR-T Cells for the Treatment of R/R Plasma Cell Neoplasms

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

August 26, 2025

Primary Completion Date

May 22, 2027

Study Completion Date

August 25, 2028

Conditions
Relapsed or Refractory Plasma Cell Neoplasms
Interventions
GENETIC

CAR19BCMA-T cells

"CAR19BCMA-T cells Each subject will be infused with single dose of CD19BCMA-CAR-T cells. A classic 3+3 dose escalation will be employed. The low dose is 1×10\^6 /kg, the medium dose is 2×10\^6 /kg, and the high dose is 3×10\^6 /kg."

DRUG

fludarabine and cyclophosphamide

"Drug: Fludarabine Fludarabine will be given at a dose of 30 mg/m2/day intravenously (IV) for 3 days prior to the infusion of CD19BCMA-CAR-T cells.~Drug: Cyclophosphamide Cyclophosphamide will be given at a dose of 300 mg/m2/day intravenously (IV) for 3 days prior to the infusion of CD19BCMA-CAR-T cells."

Trial Locations (1)

Unknown

the Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing

All Listed Sponsors
lead

Affiliated Hospital to Academy of Military Medical Sciences

OTHER