CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

June 30, 2030

Study Completion Date

December 31, 2030

Conditions
Obstructive Sleep Apnea (OSA)Mild Cognitive Impairment
Interventions
DEVICE

MAD

"Mandibular Advancement Device. It is a custom-fitted oral appliance used primarily to treat obstructive sleep apnea (OSA) and snoring. The device works by gently advancing the lower jaw (mandible) forward, which helps keep the airway open during sleep by preventing the tongue and soft tissues from collapsing and blocking the airway.~MADs are a non-invasive alternative to CPAP therapy and are especially suitable for patients with mild to moderate OSA or those who are intolerant to CPAP"

DEVICE

CPAP

"CPAP stands for Continuous Positive Airway Pressure. It is the standard treatment for obstructive sleep apnea (OSA). A CPAP machine delivers a constant stream of air through a mask worn over the nose or nose and mouth during sleep. This air pressure keeps the airway open, preventing pauses in breathing caused by airway collapse.~CPAP is highly effective, especially for moderate to severe OSA, but some patients may find it uncomfortable or difficult to tolerate."

All Listed Sponsors
collaborator

National University of Singapore

OTHER

collaborator

Ng Teng Fong General Hospital

OTHER

collaborator

Alexandra Hospital

OTHER

collaborator

National University Heart Centre, Singapore

OTHER

collaborator

The University of Sydney, Sydney, Australia

UNKNOWN

lead

National University Hospital, Singapore

OTHER