320
Participants
Start Date
September 2, 2025
Primary Completion Date
September 30, 2027
Study Completion Date
September 30, 2027
Propofol titration
Induction starts with propofol target-controlled Infusion (TCI) (Schnider model) at target effect-site drug concentration (Cet) 0.5-1.0 µg/mL and remifentanil TCI (Minto model) at Cet 0.5 ng/mL. If loss of consciousness (LOC) is not reached, propofol Cet is increased in 0.5-1.0 µg/mL steps. For intubation, remifentanil Cet increases up to 6.0 ng/mL.
Conventional propofol induction
Induction starts with propofol TCI at Cet 4-8 µg/mL and remifentanil TCI at Cet 2.5-3.5 ng/mL.
RECRUITING
University Hospital Basel, Basel
NOT_YET_RECRUITING
Kantonsspital Olten, soH, Olten
NOT_YET_RECRUITING
Kantonsspital Baden, Baden
NOT_YET_RECRUITING
Cantonal Hospital Graubünden, Chur
University of Basel
OTHER
University of Zurich
OTHER
University Hospital, Basel, Switzerland
OTHER