Cetuximab + Tislelizumab + Chemotherapy in the Treatment of Unresectable LA HNSCC

PHASE2RecruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

March 31, 2027

Study Completion Date

December 31, 2027

Conditions
LA HNSCC
Interventions
DRUG

TP + Cetuximab + Tislelizumab

"Conversion therapy stage:~TP regimen: Albumin-bound paclitaxel+Platinum (Cisplatin or Carboplatin) Albumin-bound paclitaxel: 100 mg/m² by IV infusion, D1/D8, every 3 weeks (Q3W) Platinum: Cisplatin 75 mg/m² by IV infusion or Carboplatin AUC=5 mg/mL/min Q3W Cetuximab: The initial dose is 400 mg/m² by IV infusion for 1 week. Subsequently followed by 250 mg/m² IV infusion, D1/D8, Q3W.~Tislelizumab: 200 mg by IV infusion, Q3W. 3 weeks/cycle, 3 cycles in total.~Patients who have completed conversion therapy undergo efficacy evaluation.~Radical therapy stage:~Evaluated as operable: Undergo surgery, followed by one cycle of adjuvant chemotherapy according to the preoperative regimen.~Evaluated as inoperable: Receive radical radiotherapy.~Maintenance therapy stage:~Tislelizumab for 1 year or until disease progression, intolerable toxicity, or patient refusal to continue treatment."

Trial Locations (1)

Unknown

RECRUITING

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, Chongqing

All Listed Sponsors
lead

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

OTHER