Loncastuximab and Roflumilast Added to R-CHOP (Lo-(Rituximab and Roflumilast) RR-CHOP) for Naïve High-Risk Diffuse Large B-cell Lymphoma (DLBCL)

Intravenous (IV) administration 0.15 mg/kg day 1 cycles 1-2, and 0.075mg/kg day 1, cycles 3-5

Oral administration of 500mcg days 1-21, cycles 1-8

IV administration of 375mg/m2 day 1, cycles 1-8

IV administration of 750mg/m2 day 1, cycles 3-8

IV administration 1.4mg/m2 (max 2mg) day 1, cycles 3-8

IV administration 50mg/m2 day 1, cycles 3-8

Oral administration 100mg/days 1-5, cycles 3-8