Maternal High Fibre Fermented Diet Effect on Breastfed Infant Gut Microbiome

NARecruitingINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

March 11, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

May 31, 2028

Conditions
Healthy MothersHealthy Infants
Interventions
OTHER

High Fibre Fermented Food Diet

Participants will be provided with and asked to consume specific foods high in various types of fibre to promote a variety of substrates for gut bacteria including inulin, galactooligosaccharides (GOS), and β-glucan. Participants will also be asked to consume 2 fermented items, yogurt and kefir. Study foods will be commercially available including a high-fibre bar made from chicory-derived inulin (1 bar of 35 g/d), oat-containing cakes (4 oatcakes of 35 g/d) or oat porridge (1 sachet of 38.5 g/d), shredded wheat cereal biscuits (2 biscuits of 45 g/d), hummus (½ pot of 100 g/d), and/or baked beans (½ can of 100 g/d) or lentil soup (1 can of 400 g/d), and low fat yogurt (1/3 pot of 150 g/d) and kefir (½ bottle of 250 ml/d). The total amount of fibre study foods will provide is approximately 25 g/day which will be consumed in addition to the habitual diet. The total amount of fibre will be expected to reach the 30 g/day recommendation and will range between 25 - 40 g/day.

OTHER

Control Habitual Diet

Participants will follow their habitual diet and will not consume any of the study foods (i.e., high-fibre fermented foods). The population average fibre intake for women in Scotland is 16 g/day (The Scottish Health Survey 2021).

Trial Locations (1)

G31 2ER

RECRUITING

Human Nutrition, School of Medicine, University of Glasgow, Glasgow

All Listed Sponsors
lead

University of Glasgow

OTHER