Preventing Dato-DXd Associated Stomatitis With Dexamethasone Mouthwash, TROPION-DM

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2029

Conditions
Breast NeoplasmsLung Neoplasms
Interventions
DRUG

Dexamethasone oral

Dexamethasone 10 mL daily for days 1-5 for each of the first 3 cycles of therapy Datopotamab Deruxtecan 6.0 mg/kg IV on day 1 every 21 days

Trial Locations (1)

02903/02906

Rhode Island and the Miriam Hospitals (Brown University Health), Providence

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Rhode Island Hospital

OTHER

collaborator

The Miriam Hospital

OTHER

lead

Brown University

OTHER

NCT06974604 - Preventing Dato-DXd Associated Stomatitis With Dexamethasone Mouthwash, TROPION-DM | Biotech Hunter | Biotech Hunter