Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

December 31, 2025

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2030

Conditions
Brain Metastases, AdultBrain Metastases From Non-small Cell Lung Cancer (NSCLC)
Interventions
RADIATION

Active Surveillance

Following systemic therapy, participants will undergo active surveillance with brain MRI every 3 months. Radiation therapy will only be initiated if disease progression is observed on imaging, at the discretion of the treating physician.

Trial Locations (1)

05401

University of Vermont Medical Center, Burlington

All Listed Sponsors
lead

University of Vermont Medical Center

OTHER