12
Participants
Start Date
May 5, 2025
Primary Completion Date
January 30, 2026
Study Completion Date
June 30, 2026
A/Texas/71/2017, clade 3C3a H3N2 influenza virus
The intervention product is a live challenge virus that is manufactured in the USA under Good Manufacturing Practice (GMP). The challenge will be administered intranasally using a sprayer device. Participants will be admitted into an inpatient facility prior to the administration of the flu virus. Following inoculation, they will be quarantined for a minimum of 8 days prior to discharge. Participants will receive supportive care and PCR positive participants will receive an effective antiviral medication. Participants will be followed for a total of 6 months.
Doherty Clinical Trials, Melbourne
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
WHO Collaborating Centre for Reference and Research on Influenza
UNKNOWN
University of Melbourne
OTHER