Oxybutynin ER to Promote Early Continence Recovery After Robotic Prostatectomy: A Randomized Controlled Trial

NANot yet recruitingINTERVENTIONAL
Enrollment

135

Participants

Timeline

Start Date

September 23, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2028

Conditions
Localized Prostate CancerPostoperative Urinary Incontinence
Interventions
DRUG

Oxybutynin chloride extended-release tablets 5mg/tab, 2 tab, PO, qd.

"The intervention being studied is oxybutynin chloride extended-release tablets (Oxbu), a muscarinic antagonist that is used to manage overactive bladder symptoms, including urinary incontinence. In this study, it is specifically evaluated for its potential to improve early continence recovery following robot-assisted radical prostatectomy (RARP) in patients with localized prostate cancer.~This formulation is an extended-release version of oxybutynin, which allows for a slower, sustained release of the drug over time, ensuring more consistent therapeutic effects with reduced side effects compared to immediate-release formulations. The intervention involves a daily dose of 10 mg, administered as two 5 mg tablets, to assess its impact on postoperative continence recovery.~The key distinction of this intervention is its focus on improving continence recovery after prostate cancer surgery, specifically through its targeted use in early post-surgical recovery, making it different from othe"

DRUG

Placebo (2 tab), PO, qd.

placebo, which is designed to look identical to the active drug but contains no therapeutic ingredient.

All Listed Sponsors
collaborator

Synmosa Biopharma Corp.

INDUSTRY

lead

National Taiwan University Hospital

OTHER