Adjuvant Pancreatic Therapy Guided by MRD

NARecruitingINTERVENTIONAL
Enrollment

856

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

June 1, 2028

Study Completion Date

June 1, 2030

Conditions
Pancreatic Adenocarcinoma Resectable
Interventions
DIAGNOSTIC_TEST

circulating tumor DNA (ctDNA)-based MRD

MRD testing will be performed before the start of the first treatment cycle, and at weeks 8 and 11 of each subsequent cycle. MinerVa Prime is a tumor-informed MRD assay based on a fixed panel spanning 769 cancer-related genes.

DRUG

adjuvant chemotherapy regimens

Patients will be administered with appropriate adjuvant chemotherapy regimens including but are not limited to: GEM monotherapy/adjustable GEM monotherapy, S-1 monotherapy/adjustable S-1 monotherapy, fluorouracil monotherapy/adjustable fluorouracil monotherapy, GEM plus CAP regimen/adjustable GEM plus CAP regimen, mFOLFIRINOX regimen, GEM plus nab-paclitaxel regimen/adjustable GEM plus nab-paclitaxel regimen.

Trial Locations (1)

Unknown

RECRUITING

Ruijing Hospital, Shanghai

Sponsors
All Listed Sponsors
collaborator

GeneCast Biotechnology Co., Ltd.

INDUSTRY

lead

Ruijin Hospital

OTHER