122
Participants
Start Date
June 30, 2025
Primary Completion Date
February 28, 2027
Study Completion Date
February 28, 2027
Metformin
The Metformin intervention will be self-administred capsules, taken during a 12-week period: Four weeks of dose increase; first and second week 500 mg once daily, third and fourth week 500mg twice daily. Full-dose administration (850 mg twice daily) for eight weeks.
Placebo
This intervention will be self-administered placebo capsules
Universitätsmedizin der Johannes Gutenberg-Universität Mainz (UM), Mainz
University of Warsaw, Warsaw
University Zurich (UZH), Zurich
University of Latvia
OTHER
University of Zurich
OTHER
Johannes Gutenberg University Mainz
OTHER
University of Warsaw
OTHER
Leibniz-Institut für Resilienzforschung (LIR) gGmbH
OTHER