NCT06965413View on ClinicalTrials.gov

A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity

PHASE2RecruitingINTERVENTIONAL
Enrollment

234

Participants

Timeline

Start Date

May 5, 2025

Primary Completion Date

October 23, 2026

Study Completion Date

September 20, 2027

Conditions
ObesityOverweightOverweight With One Weight Related Comorbidity
Interventions
DRUG

RO7204239

RO7204239 or matching placebo will be administered as per the schedule specified in the arms.

DRUG

RO7204239 Matching Placebo

RO7204239 matching placebo will be administered as per the schedule specified in the arm.

DRUG

Tirzepatide

Tirzepatide will be administered as per the schedule specified in the arms.

Trial Locations (36)

14609

RECRUITING

Rochester Clinical Research, Rochester

15006

RECRUITING

Hospital San Rafael A Coruna, A Coruña

20110

RECRUITING

Manassas Clinical Research Center, Manassas

27103

RECRUITING

Accellacare Research of Winston Salem, Winston-Salem

28144

RECRUITING

Accellacare of Salisbury, Salisbury

28401

RECRUITING

Accellacare of Wilmington, LLC, Wilmington

28625

RECRUITING

Accellacare of Piedmont Healthcare, Statesville

29010

RECRUITING

Hospital Universitario Virgen de la Victoria, Málaga

30291

RECRUITING

Rophe Adult and Pediatric Medicine/SKYCRNG, Union City

32806

RECRUITING

K2 Medical Research South Orlando, LLC, Orlando

36207

RECRUITING

Pinnacle Research Group, Anniston

37203

RECRUITING

Clinical Research Associates, Nashville

37620

RECRUITING

Accellacare of Bristol/ Internal Medicine & Pediatrics, Bristol

37912

RECRUITING

Accellacare of Knoxville, Knoxville

39008

RECRUITING

Hospital Universitario Marques de Valdecilla, Santander

41009

RECRUITING

Universidad de Sevilla - Hospital Universitario Virgen Macarena, Seville

41950

RECRUITING

Hospital Vithas Nisa Sevilla, Castilleja de la Cuesta

45801

RECRUITING

NexGen Research, Lima

60453

RECRUITING

Accellacare of Duly Health and Care, Oak Lawn

76710

RECRUITING

Velocity Clinical Research (Impact Research Institute), Waco

77040

RECRUITING

Juno Research, LLC, Houston

78231

RECRUITING

Consano Clinical Research, Shavano Park

78731

RECRUITING

Texas Diabetes & Endocrinology, P.A., Austin

91978

RECRUITING

Encompass Clinical Research, Spring Valley

06708-3346

WITHDRAWN

Chase Medical Research, Waterbury

80-546

RECRUITING

Centrum Badan Klinicznych PI-House sp. z o.o., Gdansk

30-033

RECRUITING

Centrum Medyczne ALL-MED, Krakow

20-718

RECRUITING

Ekamed sp. z o.o., Lublin

02-677

RECRUITING

ETG Warszawa, Warsaw

08035

RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

FY3 7EN

RECRUITING

Fylde Coast Clinical Research at Layton Medical Centre, Blackpool

LE5 4PW

RECRUITING

University Hospitals of Leicester NHS Trust - Leicester General Hospital (LGH), Leicester

BD18 3SA

RECRUITING

Accellacare Yorkshire, Shipley

CV3 4FJ

RECRUITING

Accellacare Warwickshire, Coventry

HA6 2RN

RECRUITING

Accellacare North London, Northwood

BR5 3QG

RECRUITING

Accellacare South London, Orpington

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY