Comparing ASCT Followed by Anti-BCMA CAR-T vs. ASCT Alone in NDMM Patients Eligible for ASCT

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

May 1, 2025

Primary Completion Date

April 30, 2028

Study Completion Date

April 30, 2028

Conditions
Multiple Myeloma, Newly Diagnosed
Interventions
BIOLOGICAL

autologous stem cell transplantation

Patients in this arm will receive autologous hematopoietic stem cell transplantation (ASCT). Prior to ASCT, the patients underwent 3-4 cycles of induction chemotherapy.

BIOLOGICAL

CAR-T

The T cells are genetically modified to express a chimeric antigen receptor targeting BCMA and are infused 3 days after ASCT at a target dose of ≥2.0×10\^6 cells/kg.

Trial Locations (1)

221006

The Affiliated Hospital oh Xuzhou Medical University, Xuzhou

All Listed Sponsors
lead

Xuzhou Medical University

OTHER