100
Participants
Start Date
September 1, 2025
Primary Completion Date
August 31, 2027
Study Completion Date
August 31, 2027
MM+
Participants in both study arms will receive clinic-based HIV counseling, including urine tenofovir testing and biofeedback counseling on recent PrEP or ART use. Activities unique to women enrolled in the intervention arm include: Brief motivational interviewing sessions with a mentor mother focusing on 1) EtG testing and biofeedback on recent alcohol use, 2) counseling and mentorship on ways to reduce alcohol use.
Enhanced HIV attention control (eSOC)
Participants in the enhanced HIV attention control arm (comparison group) will attend a similar number of study visits within the same time frame as intervention participants (5-6 sessions during 6-month timeframe including both pregnancy and postpartum). Control arm sessions will consist of one-on-one educational counseling on HIV risk, partner HIV testing modalities, as well as conducting PrEP/ART urine assay testing followed by real-time in-clinic adherence counseling delivered privately (different from study nurses delivering PrEP/ART biofeedback in MM+ intervention arm to avoid contamination), all coinciding with routine ANC visits.
Saldanha Bay Municipality Clinic, Cape Town
University of Cape Town
OTHER
San Diego State University
OTHER
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
University of California, Los Angeles
OTHER