Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)

PHASE3RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

May 15, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

October 31, 2028

Conditions
Urinary Bladder NeoplasmsImmune Checkpoint InhibitorsMethotrexateVinblastineDoxorubicinCisplatinGemcitabine
Interventions
DRUG

Durvalumab

Anti- PD-L1 Antibody.

DRUG

Methotrexate

Chemotherapy agent.

DRUG

Vinblastine

Chemotherapy agent

DRUG

Doxorubicin

Chemotherapy agent

DRUG

Cisplatin

Chemotherapy agent

DRUG

Durvalumab

Anti- PD-L1 Antibody

DRUG

Gemcitabine

Chemotherapy agent

DRUG

Cisplatin

Chemotherapy agent

Trial Locations (54)

2065

RECRUITING

Research Site, St Leonards

2109

RECRUITING

Research Site, Macquarie University

2217

NOT_YET_RECRUITING

Research Site, Kogarah

2444

NOT_YET_RECRUITING

Research Site, Port Macquarie

3084

NOT_YET_RECRUITING

Research Site, Heidelberg

4032

RECRUITING

Research Site, Chermside

5112

RECRUITING

Research Site, Elizabeth Vale

6150

NOT_YET_RECRUITING

Research Site, Murdoch

8003

NOT_YET_RECRUITING

Research Site, Barcelona

10043

NOT_YET_RECRUITING

Research Site, Orbassano

13009

NOT_YET_RECRUITING

Research Site, Marseille

15706

NOT_YET_RECRUITING

Research Site, Santiago de Compostela

17007

NOT_YET_RECRUITING

Research Site, Girona

21079

NOT_YET_RECRUITING

Research Site, Dijon

27003

NOT_YET_RECRUITING

Research Site, Lugo

28033

NOT_YET_RECRUITING

Research Site, Madrid

28040

NOT_YET_RECRUITING

Research Site, Madrid

30029

NOT_YET_RECRUITING

Research Site, Nîmes

31130

NOT_YET_RECRUITING

Research Site, Quint-Fonsegrives

33075

NOT_YET_RECRUITING

Research Site, Bordeaux

34070

NOT_YET_RECRUITING

Research Site, Montpellier

35000

NOT_YET_RECRUITING

Research Site, Rennes

35016

NOT_YET_RECRUITING

Research Site, Las Palmas de Gran Canaria

37170

NOT_YET_RECRUITING

Research Site, Chambray-lès-Tours

49055

NOT_YET_RECRUITING

Research Site, Angers

49933

NOT_YET_RECRUITING

Research Site, Angers

50139

NOT_YET_RECRUITING

Research Site, Florence

59037

NOT_YET_RECRUITING

Research Site, Lille

67033

NOT_YET_RECRUITING

Research Site, Strasbourg

69008

NOT_YET_RECRUITING

Research Site, Lyon

69310

NOT_YET_RECRUITING

Research Site, Pierre-Bénite

75010

NOT_YET_RECRUITING

Research Site, Paris

75900

NOT_YET_RECRUITING

Research Site, Paris

76230

NOT_YET_RECRUITING

Research Site, Rouen

86021

NOT_YET_RECRUITING

Research Site, Poitiers

92150

NOT_YET_RECRUITING

Research Site, Suresnes

Unknown

NOT_YET_RECRUITING

Research Site, Hong Kong

14784-400

NOT_YET_RECRUITING

Research Site, Barretos

91350-200

NOT_YET_RECRUITING

Research Site, Porto Alegre

09060-650

NOT_YET_RECRUITING

Research Site, Santo André

01246-000

NOT_YET_RECRUITING

Research Site, São Paulo

L8V 5C2

NOT_YET_RECRUITING

Research Site, Hamilton

N6A 5W9

NOT_YET_RECRUITING

Research Site, London

K1H 8L6

WITHDRAWN

Research Site, Ottawa

G1J 1Z4

NOT_YET_RECRUITING

Research Site, Québec

J1H 5N4

RECRUITING

Research Site, Sherbrooke

06189

NOT_YET_RECRUITING

Research Site, Nice

00144

NOT_YET_RECRUITING

Research Site, Roma

1066CX

NOT_YET_RECRUITING

Research Site, Amsterdam

6500 HB

NOT_YET_RECRUITING

Research Site, Nijmegen

3015 GD

NOT_YET_RECRUITING

Research Site, Rotterdam

08025

NOT_YET_RECRUITING

Research Site, Barcelona

08035

NOT_YET_RECRUITING

Research Site, Barcelona

08036

NOT_YET_RECRUITING

Research Site, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY