NCT06960369View on ClinicalTrials.gov

Efficacy of Repeated Transcranial Magnetic Stimulation Combined With a Live Probiotic Tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus Tablets, Live) in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)

PHASE1RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

December 1, 2024

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2026

Conditions
Irritable Bowel SyndromeIrritable Bowel Syndrome With Diarrhea (IBS-D)Repetitive Transcranial Magnetic Stimulation (rTMS)ProbioticChronic DiarrheaIntestinal Flora
Interventions
COMBINATION_PRODUCT

rTMS combined with Live Probiotic tablet

rTMS group received 1 Hz/s, 20 min for 2 week; Live Probiotic tablet group received tablets orally, 150 mg three times a day for 2 week.

DEVICE

rTMS combined placebo

rTMS group received 1 Hz/s, 20 min for 2 week; placebo group received tablets orally, 150 mg three times a day for 2 week.

DRUG

shamrTMS combined with Live Probiotic tablet

Live Probiotic tablet group received tablets orally, 150 mg three times a day for 2 week, shamrTMS group received 0 Hz/s, 20 min for 2 week.

OTHER

shamrTMS combined placebo group

shamrTMS group received 0 Hz/s, 20 min for 2 week; placebo group received tablets orally, 150 mg three times a day for 2 week.

Trial Locations (1)

215006

RECRUITING

The First Affiliated Hospital of Soochow University, Suzhou

All Listed Sponsors
collaborator

Soochow University

OTHER

lead

The First Affiliated Hospital of Soochow University

OTHER