A Clinical Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Inhaled H057 in the Treatment of Acute Exacerbations of Bronchiectasis

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

May 31, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Acute Exacerbations of Bronchiectasis
Interventions
DRUG

Low-dose H057+standard-of-care

Subjects are administered low-dose inhaled H057, combined with standard-of-care treatment, which included anti-infective therapy, expectorant therapy, hemostasis, oxygen therapy, and other supportive measures.

DRUG

High-dose H057+standard-of-care

Subjects are administered high-dose inhaled H057, combined with standard-of-care treatment, which included anti-infective therapy, expectorant therapy, hemostasis, oxygen therapy, and other supportive measures.

DRUG

H057 placebo+standard-of-care

Subjects are administered inhaled H057 placebo, combined with standard-of-care treatment, which included anti-infective therapy, expectorant therapy, hemostasis, oxygen therapy, and other supportive measures.

Trial Locations (19)

Unknown

Fuyang Hospital Of Anhui Medical University, Fuyang

Hefei First People's Hospital, Hefei

Fujian Medical University Union Hospital, Fuzhou

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

Peking University Shenzhen Hospital, Shenzhen

Affiliated hospital of Youjiang Medical University For Nationalities, Baise City

Hebei General Hospital, Shijiazhuang

Nanyang Second General Hospital, Nanyang

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

Yichang Central People's Hospital, Yichang

The second Xiangya Hospital of Central South University, Changsha

Changzhou First People's Hospital, Changzhou

Jiujiang No.1 People's Hospital, Jiujiang

Sichuan Provincial People's Hospital, Chengdu

Deyang People's Hospital, Deyang

Hangzhou First People's Hospital, Hangzhou

Jinhua Municipal Central Hospital, Jinhua

Ningbo No.2 Hospital, Ningbo

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

All Listed Sponsors
lead

Shanghai Huilun Pharmaceutical Co., Ltd.

INDUSTRY