Sirolimus for Injection (Albumin-bound) in Combination With Endocrine Therapy for HR+/HER2- Advanced/Metastatic Breast Cancer Patients Who Have Failed Standard Therapy

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

February 29, 2024

Primary Completion Date

June 30, 2025

Study Completion Date

December 31, 2025

Conditions
HR+/HER2- Advanced/Metastatic Breast Cancer
Interventions
DRUG

Letrozole

Oral administration at a dose of 2.5 mg once daily for a 4-week cycle

DRUG

Anastrozole

Oral administration at a dose of 1 mg once daily for a 4-week cycle

DRUG

Exemestane

Oral administration at a dose of 25 mg once daily with a meal every 4 weeks

DRUG

Fulvestrant

Fulvestrant: IM injection, 500 mg, on day 1 and day 15 of Cycle 1, and then on day 1 of each cycle thereafter, 4 weeks per treatment cycle

DRUG

Sirolimus for Injection (Albumin-bound)

IV infusion, every 2 weeks, 4 weeks per treatment cycle

Trial Locations (1)

Unknown

Cancer Hospital, Chinese Academy of Medical Sciences, Beijing

All Listed Sponsors
lead

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

INDUSTRY

NCT06957379 - Sirolimus for Injection (Albumin-bound) in Combination With Endocrine Therapy for HR+/HER2- Advanced/Metastatic Breast Cancer Patients Who Have Failed Standard Therapy | Biotech Hunter | Biotech Hunter