Firmonertinib Versus Platinum Based Chemotherapy as First-line Treatment for NSCLC With EGFR PACC or EGFR l861q Mutation

PHASE3RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

November 19, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

July 31, 2028

Conditions
EGFRNSCLC (Advanced Non-small Cell Lung Cancer)
Interventions
DRUG

Firmonertinib Mesilate Tablets

Usage and dosage: oral, 240mg, QD。 Medication duration: 21 days as a cycle, until intolerable toxicity, loss of clinical benefit, disease progression (confirmed by BICR), death or other anti-tumor treatment (whichever occurs first).

DRUG

Pemetrexed Disodium for Injection

Usage and dosage: 500mg/m2, intravenous infusion. Medication duration: 21 days as a cycle, D1 administration, until the occurrence of intolerable toxicity, loss of clinical benefit, disease progression (confirmed by BICR), death or other anti-tumor treatment (whichever occurs first).

DRUG

Cisplatin for injection

Usage and dosage: 75 mg/m2, i.v. Medication duration: 21 days as a cycle, D1 administration, up to 4 cycles.

DRUG

Carboplatin Injection

"Usage and dosage: give the drug according to AUC 5 mg/ml, intravenous drip.~Medication duration: 21 days as a cycle, D1 administration, up to 4 cycles."

Trial Locations (2)

100021

RECRUITING

Ethics Committee of cancer hospital, Chinese Academy of Medical Sciences, Beijing

Unknown

RECRUITING

Shandong Tumor Hospital, Shandong

Sponsors
All Listed Sponsors
lead

Allist Pharmaceuticals, Inc.

INDUSTRY