JS207 Combined With JS007 as First-line Treatment for Advanced Hepatocellular Carcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

May 29, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

June 30, 2028

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

JS207

10 mg/kg q3W or adjust the dose (e.g. 15 mg/kg) based on accumulated data on the safety and efficacy of JS207 from clinical studies.

DRUG

JS007

Dose exploration stage: C1-C4, group 1:3 mg/kg, C1D1 once (single dose); Group 2:3 mg/kg, D1, Q6W; Group 3:1 mg/kg,D1, Q3W; ≥C5, 1 mg/kg, Q6W; Dose expansion stage: according to the group medication confirmed in the dose exploration stage.

Trial Locations (12)

100005

RECRUITING

Peking Union Medical College Hospital, Beijing

100021

NOT_YET_RECRUITING

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

110801

NOT_YET_RECRUITING

The First Hospital of China Medical University, Shenyang

130061

RECRUITING

Zhongshan Hospital affiliated to Fudan University, Shanghai

150081

NOT_YET_RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200025

RECRUITING

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine City:Shanghai, Shanghai

200120

NOT_YET_RECRUITING

Shanghai East Hospital,School of Medicine, Tongji University, Shanghai

230022

RECRUITING

The First Affiliated Hospital of USTC, Hefei

330006

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

410000

NOT_YET_RECRUITING

Hunan Cancer Hospital, Changsha

NOT_YET_RECRUITING

Hunan Cancer Hospital, Changsha

451191

NOT_YET_RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

All Listed Sponsors
lead

Shanghai Junshi Bioscience Co., Ltd.

OTHER