Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

PHASE4RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

April 21, 2025

Primary Completion Date

March 31, 2027

Study Completion Date

June 30, 2027

Conditions
Pain, PostoperativeAnkle Fracture SurgeryOpioid Use DisorderOpioid DependenceOpioid Analgesia
Interventions
DRUG

Buprenorphine Transdermal System

The buprenorphine transdermal system is unique from other interventions in the study, as it is the experimental drug in the study. The buprenorphine transdermal system will be applied in the pre-operative holding area. Aside from the buprenorphine transdermal system, participants assigned to this intervention will otherwise receive the standard of care in their post-operative pain management following ankle fracture surgery.

DRUG

Placebo Patch

The placebo patch is unique from other interventions in the study, as it is the placebo drug in the study. The placebo patch will be applied in the pre-operative holding area. Aside from the placebo patch, participants assigned to this intervention will otherwise receive the standard of care in their post-operative pain management following ankle fracture surgery.

Trial Locations (1)

63110

RECRUITING

Washington University in St. Louis/Barnes Jewish Hospital, St Louis

All Listed Sponsors
collaborator

The Foundation for Barnes-Jewish Hospital

OTHER

collaborator

Washington University Institute of Clinical and Translational Sciences

UNKNOWN

lead

Jenna-Leigh Wilson

OTHER