A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants

PHASE1CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

May 6, 2025

Primary Completion Date

October 3, 2025

Study Completion Date

October 3, 2025

Conditions
Healthy Participants
Interventions
DRUG

AZD5004

"Participants will receive oral tablets of AZD5004 as single dose on the following days, (i) Day 7, Day 14, Day 21, Day 28, Day 35, Day 42 and Day 55 in Part A. (ii) Day 9 to Day15, Day 16, Day 17 to Day 23, Day 24 to Day 30, Day 31 to Day 37, Day 38 to Day 41 and Day 42 in Part B.~(iii) Day 3 to Day 9, Day 10 to Day 25, Day 26 to Day 33, and Day 34 in Part C."

DRUG

Rosuvastatin

Participants will receive single oral tablets of rosuvastatin 10mg on Days 1, 7, 14, 21, 28, and 35.

DRUG

Erythromycin

Participants will receive oral doses of erythromycin 500 mg, twice a day from Day 49 to Day 54; and a single dose of 500 mg on Day 55.

DRUG

Atorvastatin

Participants will receive single oral doses of 40 mg atorvastatin on Days 4, 8, 16, 38, and 42.

DRUG

Simvastatin

Participants will receive single oral doses of 20 mg simvastatin on Days 1 and 31.

DRUG

Repaglinide

Participants will receive single oral doses of 0.5 mg repaglinide on Days 1, 10, 26, and 34.

Trial Locations (1)

21225

Research Site, Brooklyn

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY