Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment

NANot yet recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
CreatineExerciseMild Cognitive Impairment (MCI)
Interventions
DIETARY_SUPPLEMENT

Creatine monohydrate

Participants will consume one serving of creatine daily (0.10g of creatine/kg of body weight). This relative dosing approach ensures that smaller participants do not receive excessive doses, while larger participants receive an adequate amount. There is currently limited evidence to conclude the effectiveness of timing daily creatine intake, but it is recommended that creatine be consumed at mealtime for optimal absorption. Participants will choose what meal they will take the supplement and will be asked to keep timing consistent throughout the study. This daily low dose method was chosen because other methods (high-dose loading) may have negative side effects (e.g., water retention, cramping).

BEHAVIORAL

Resistance training

Participants will use the programmable weight machines along with free weights to target primary muscle groups. In addition, they will complete mini-squats, mini-lunges, and lunge walks. Participants will complete two sets of 6-8 reps. Training stimulus will be increased using the 7RM method - when 2 sets of 6-8 reps are completed with proper form and without discomfort. The investigators will record the number of sets completed and the load lifted for each exercise for each participant at every class.

Trial Locations (1)

N6E 1Z6

Western University, London

All Listed Sponsors
collaborator

Alzheimer Society of Canada

OTHER

lead

Western University, Canada

OTHER

NCT06948149 - Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment | Biotech Hunter | Biotech Hunter