Comparison of Neoadjuvant Cadonilimab Versus Chemotherapy Combined With PD-1 in the Treatment of Resectable Non-Small Cell Lung Cancer With High PD-L1 Expression: A Single-Center, Randomized, Exploratory Clinical Study

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

April 21, 2025

Primary Completion Date

May 1, 2031

Study Completion Date

May 11, 2031

Conditions
Resectable Non-small Cell Lung CancerBispecific AntibodyNeoadjuvant Therapy
Interventions
DRUG

AK104

Eligible patients will be randomly assigned in a 1:1 ratio to either the PD-1 combined with chemotherapy group or the AK104 monotherapy group. Treatment will be administered every 3 weeks, with patients undergoing three preoperative treatment cycles before surgery.

All Listed Sponsors
lead

Shanghai Pulmonary Hospital, Shanghai, China

OTHER