NCT06946615View on ClinicalTrials.gov

Exploratory Clinical Study of Claudin18.2-Targeted CAR-DC and CAR-T Therapy in Advanced Colorectal Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

April 8, 2025

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2027

Conditions
Colorectal Neoplasia
Interventions
BIOLOGICAL

Claudin18.2-targeted CAR-T Cells

Autologous T cells genetically modified to express a chimeric antigen receptor (CAR) targeting Claudin18.2.

BIOLOGICAL

Claudin18.2-targeted CAR-DCs

Autologous dendritic cells (DCs) genetically modified to express a chimeric antigen receptor (CAR) targeting Claudin18.2.

Trial Locations (1)

310009

RECRUITING

Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou

All Listed Sponsors
lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER