Rituximab, Methotrexate, and Tepadina Induction Followed by Etoposide and Cytarabine Consolidation in Primary Central Nervous System Lymphoma

NARecruitingINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

December 2, 2022

Primary Completion Date

December 1, 2027

Study Completion Date

December 1, 2029

Conditions
Primary Central Nervous System Lymphoma (PCNSL)CNS Lymphoma Treatment
Interventions
DRUG

Rituximab, Methotrexate, and Thiotepa (R-MT) Induction Followed by Etoposide and Cytarabine (EA) Consolidation

"Pre-induction Therapy (R-M regimen):~Cycle 1-2 (C1-C2):~Rituximab (R): 375 mg/m² IV, on Day 1 Methotrexate (MTX): 3.5 g/m² IV over 3 hours, on Day 2~Induction Therapy (R-MT regimen):~Cycle 3-6 (C3-C6):~Rituximab (R): 375 mg/m² IV, on Day 1 Methotrexate (MTX): 3.5 g/m² IV over 3 hours, on Day 2 Thiotepa (T): 30 mg/m² IV over 30 minutes, on Day 3~Consolidation Therapy (EA regimen):~Cycle 7-8 (C7-C8):~Etoposide (E): 5 mg/kg IV, every 12 hours on Days 1 and 2 Cytarabine (A): 2.0 g/m² IV over 2 hours, every 12 hours on Days 3 and 4"

Trial Locations (1)

Unknown

RECRUITING

Facility Name: The First Hospital of Jilin University, Changchun

All Listed Sponsors
lead

FengYan Jin

OTHER