Clinical Study on Chimeric Antigen Receptor T Lymphocyte (CAR-T) Targeting CEA for the Treatment of CEA - Positive Advanced Lung Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

April 28, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

April 30, 2028

Conditions
Advanced Lung Cancer
Interventions
BIOLOGICAL

Targeted CEA CAR-T

Subjects meeting the transfusion criteria will receive pre-treatment, which is as follows: fludarabine 25mg/m2/d×3day and cyclophosphamide 300mg/m2/d×3day, and intravenous CEA CAR-T therapy after 1-2 days of rest

BIOLOGICAL

Targeted CEA CAR-T

Subjects meeting the reinfusion criteria will receive pre-treatment with fludarabine 25mg/m2/d×3day and cyclophosphamide 300mg/m2/d×3day, rest for 1-2 days, and intraperitoneal reinfusion targeted CEA CAR-T therapy

Trial Locations (1)

430030

RECRUITING

Wuhan Pulmonary Hospital, Wuhan

All Listed Sponsors
lead

Chongqing Precision Biotech Co., Ltd

INDUSTRY