A Study of Switching to Picankibart in Chinese Patients With Plaque Psoriasis With an Inadequate Response to Interleukin-17 Monoclonal Antibody Therapy

PHASE3RecruitingINTERVENTIONAL
Enrollment

310

Participants

Timeline

Start Date

May 27, 2025

Primary Completion Date

June 7, 2026

Study Completion Date

January 19, 2027

Conditions
Plaque Psoriasis
Interventions
DRUG

Picankibart

"The participants in picankibart treatment group will receive picankibart 200mg SC at Weeks 0, 4, 8, 20 and 32.~The participants in IL-17 mAb continued treatment group will receive picankibart 200mg SC at Weeks 16, 20, 24 and 36."

DRUG

Secukinumab

The participants in IL-17 mAb continued treatment group who have received secukinumab before enrollment, will receive secukinumab 300mg SC at Weeks 0, 4, 8 and 12.

DRUG

Placebo

"The participants in picankibart treatment group will receive placebo SC at Weeks 12, 16, 24 and 36.~The participants in IL-17 mAb continued treatment group will receive placebo SC at Week 32."

DRUG

Ixekizumab

The participants in IL-17 mAb continued treatment group who have received ixekizumab before enrollment, will receive ixekizumab 80mg SC at Weeks 0, 4, 8 and 12.

Trial Locations (1)

250000

RECRUITING

Dermatology Hospital of Shandong First Medical University (Shandong Provincial Hospitial of Dermatology), Jinan

All Listed Sponsors
lead

Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD.

INDUSTRY