JS207 Combined With Chemotherapy in Subjects With Stage II-III NSCLC

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

76

Participants

Timeline

Start Date

April 20, 2025

Primary Completion Date

September 30, 2026

Study Completion Date

December 31, 2027

Conditions
NSCLC
Interventions
DRUG

Paclitaxel + Carboplatin/cisplatin for squamous cell carcinoma and pemetrexed + carboplatin/cisplatin for non-squamous cell carcinoma

"Carboplatin Injection:~One dose of carboplatin AUC 5 IV on Day 1 of each 3-week cycle.~Cisplatin injection:~Cisplatin 75 mg/m2 IV on Day 1 of every 3-week cycle.~Paclitaxel injection:~175 mg/m2 IV on Day 1 of each 3-week cycle.~Pemetrexed Injection:~Pemetrexed 500 mg/m2 IV on Day 1 of each 3-week cycle."

PROCEDURE

surgery

Subjects with surgical indications will undergo radical surgery for NSCLC,within 4-6 weeks after the last dose of neoadjuvant therapy.

RADIATION

Radiochemotherapy

If radical surgery is not suitable after MDT evaluation, the subjects will receive comprehensive treatment mainly based on radiotherapy.

DRUG

JS207

JS207 will be administered every 3 weeks for a treatment cycle of 21 days.

Trial Locations (1)

510080

Guangdong Provincial People's Hospital, Guangzhou

All Listed Sponsors
lead

Shanghai Junshi Bioscience Co., Ltd.

OTHER