Ketamine for Opioid Use Disorder

Participants will receive four doses of ketamine spaced 1-6 days apart of 0.75 mg/kg intramuscular ketamine (n=25) for two weeks (first ketamine session must occur no later than 28 days post-intake). Individuals will be monitored for two hours post-dose by a clinician.

Participants will receive four doses of an active placebo (diphenhydramine 50 mg) (n=25) spaced 1-6 days apart for two weeks (first placebo session must occur no later than 28 days post-intake). Individuals will be monitored for two hours post-dose by a clinician.