An Open-Label Study of Effectiveness of Immunomodulatory Medications for Patients With Relapsing Polychondritis

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

July 31, 2027

Study Completion Date

December 31, 2027

Conditions
Relapsing Polychondritis
Interventions
DRUG

Methotrexate (MTX)

Weekly methotrexate dose of 20 mg (oral or subcutaneous).

DRUG

Azathioprine (AZA)

Azathioprine dose will be 2-3 mg/kg body weight per day.

BIOLOGICAL

Adalimumab

Adalimumab dose will be 40 mg subcutaneously every 1-2 weeks

BIOLOGICAL

Infliximab

Infliximab dose will be 5mg/kg at week 0 and week 2, and then every 4-8 weeks.

BIOLOGICAL

Tocilizumab

Tocilizumab dose will be 162 mg subcutaneous injection every week or 4-8 mg/kg every 4 weeks

Trial Locations (1)

19104

RECRUITING

University of Pennsylvania, Philadelphia

All Listed Sponsors
lead

University of Pennsylvania

OTHER