Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 )

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

August 31, 2026

Study Completion Date

December 31, 2026

Conditions
Small Cell Lung Cancer Extensive StageMerkel Cell Carcinoma
Interventions
DRUG

225Ac-SSO110 + SoC

Dose Level -2-7

DRUG

Atezolizumab

Extensive Stage Small Cell Lung Cancer Checkpoint Inhibitor (SoC)

DRUG

Durvalumab

Extensive Stage Small Cell Lung Cancer Checkpoint Inhibitor (SoC)

DRUG

Avelumab

Merkel Cell Carcinoma Checkpoint Inhibitor (SoC)

DRUG

Pembrolizumab

Merkel Cell Carcinoma Checkpoint Inhibitor (SoC)

DRUG

Retifanlimab

Merkel Cell Carcinoma Checkpoint Inhibitor (SoC)

Trial Locations (5)

15219

RECRUITING

UPMC, Pittsburgh

21061

RECRUITING

United Theranostics, Glen Burnie

22031

RECRUITING

Virginia Cancer Specialists, PC, Fairfax

33165

RECRUITING

Biogenix Molecular, Miami

40202

RECRUITING

University of Louisville Health-Brown Cancer Center, Louisville

Sponsors
All Listed Sponsors
lead

Ariceum Therapeutics GmbH

INDUSTRY

NCT06939036 - Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 ) | Biotech Hunter | Biotech Hunter