Tarlatamab vs Standard of Care Chemotherapy in Patients With Pre-treated Advanced, Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Carcinomas (NECs)

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

September 1, 2028

Study Completion Date

March 1, 2030

Conditions
Neuroendocrine Carcinoma
Interventions
DRUG

Standard of Care Chemotherapy

Study treatment in the arm A is left to the investigator appreciations. This may include immune checkpoint inhibitors, docetaxel, topotecan for primary lung tumors, and FOLFOX, FOLFIRI or alkylating-based chemotherapy in primary digestive tumors.

DRUG

Tarlatamab

Tarlatamab 10 mg every 2 weeks

Trial Locations (40)

Unknown

Angers - CHU, Angers

Avignon - CH, Avignon

Besançon - CHU, Besançon

Boulogne - Ambroise Paré, Boulogne

Caen - CHU, Caen

Caen - CHU, Caen

Tours - CHU, Chambray-lès-Tours

Dijon - Centre Georges-François Leclerc, Dijon

Dijon - CHU Bocage, Dijon

Grenoble - CHU, Grenoble

Le Mans - CHG, Le Mans

Lille - Centre Oscar Lambret, Lille

Limoges - CHU, Limoges

Limoges - CHU, Limoges

Lyon - Centre Léon Bérard, Lyon

Lyon - Hôpital Edouard Herriot, Lyon

Lyon - Hôpital Privé Jean Mermoz, Lyon

Marseille - APHM, Marseille

Marseille - Institut Paoli-Calmettes, Marseille

Montpellier - CHU, Montpellier

Nice - Centre Antoine Lacassagne, Nice

Paris - Curie, Paris

Paris - Hôpital Cochin, Paris

Paris - Saint-Antoine, Paris

Paris - Tenon, Paris

Bordeaux - CHU, Pessac

Bordeaux - CHU, Pessac

Lyon - HCL, Pierre-Bénite

Poitiers - CHU, Poitiers

Reims - CHU, Reims

Rennes - CHU, Rennes

Rouen - CHU, Rouen

Nantes - Hôpital Laennec, Saint-Herblain

Nantes - Institut de Cancérologie de l'Ouest, Saint-Herblain

Strasbourg - Nouvel Hôpital Civil, Strasbourg

Toulon - CHI, Toulon

Toulouse - CHU, Toulouse

Tours - CHU, Tours

Vandoeuvre-lès-Nancy - Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

Villefranche sur Saône - CH, Villefranche-sur-Saône

All Listed Sponsors
lead

Intergroupe Francophone de Cancerologie Thoracique

OTHER

NCT06937905 - Tarlatamab vs Standard of Care Chemotherapy in Patients With Pre-treated Advanced, Pulmonary or Gastroenteropancreatic Poorly Differentiated Neuroendocrine Carcinomas (NECs) | Biotech Hunter | Biotech Hunter