NCT06937320 - Chronic Exogenous Ketosis in HFpEF | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

July 28, 2025

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions

Heart Failure With Preserved Ejection Fraction (HFPEF)Heart Failure With Normal Ejection FractionHeart Failure, Diastolic

Interventions

DIETARY_SUPPLEMENT

Exogenous Ketone Drink

"(R)-1,3-butanediol (BD, commercially available as KetoneIQ) initially dosed 300 mg/kg BID (target dose 400 mg/kg grams BID if tolerated) for 8 weeks"

DIETARY_SUPPLEMENT

Placebo

equi-volume placebo administered for 8 weeks

Trial Locations (1)

27710

Duke University, Durham