58
Participants
Start Date
April 28, 2025
Primary Completion Date
December 31, 2025
Study Completion Date
January 31, 2026
Metformin
Participants are administered metformin with an initial dose of 500 mg/day, which was incrementally increased by 500 mg/day each week until the maximum tolerated dose. The maximum dose of metformin is set at 2000 mg/day.
Placebo
Participants are administered a placebo, starting with one tablet per day, followed by an incremental increase of one tablet per week. In the absence of adverse reactions, the dosage is escalated up to a maximum of four tablets per day.
RECRUITING
Changhai Hospital, Shanghai
Changhai Hospital
OTHER