MAGIC Ruxolitinib for aGVHD

PHASE2RecruitingINTERVENTIONAL
Enrollment

98

Participants

Timeline

Start Date

May 14, 2025

Primary Completion Date

June 1, 2027

Study Completion Date

April 14, 2028

Conditions
Acute Graft-versus-host DiseaseAllogeneic Bone Marrow TransplantationAdverse Effects
Interventions
DRUG

Ruxolitinib

Ruxolitinib twice daily for 56 days followed by a short taper Given orally

DRUG

Methylprednisolone

Starting dose 2 mg/kg/d for at least three days, then taper Given IV or orally

Trial Locations (11)

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

30322

NOT_YET_RECRUITING

Winship Cancer Institute, Emory University, Atlanta

33612

NOT_YET_RECRUITING

Moffitt Cancer Center, Tampa

43210

NOT_YET_RECRUITING

Ohio State University, Columbus

55905

NOT_YET_RECRUITING

Mayo Clinic, Rochester

63110

NOT_YET_RECRUITING

Washington University, St Louis

77030

NOT_YET_RECRUITING

MD Anderson Cancer Center, Houston

91010

NOT_YET_RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

98109

NOT_YET_RECRUITING

Fred Hutchinson Cancer Research Center, Seattle

02114

NOT_YET_RECRUITING

Massachusetts General Hospital, Boston

02115

NOT_YET_RECRUITING

Dana Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Incyte Corporation

INDUSTRY

collaborator

National Cancer Institute (NCI)

NIH

lead

John Levine

OTHER