Revised Targets for Knee Radiofrequency Ablation

RecruitingOBSERVATIONAL
Enrollment

60

Participants

Timeline

Start Date

March 20, 2025

Primary Completion Date

July 14, 2028

Study Completion Date

July 30, 2031

Conditions
Osteoarthritis Knee Pain
Interventions
DEVICE

Ultrasound-Guided Genicular Nerve Radiofrequency Ablation

This intervention involves a single-session ultrasound-guided thermal radiofrequency ablation of the superomedial, superolateral, and inferomedial genicular nerves in patients with moderate to severe knee osteoarthritis. Target points follow anatomical references described by Fonkoue et al. and validated in cadaveric studies, differing from classical approaches. Under ultrasound guidance, monopolar RF cannulas are placed, with sensory and motor stimulation confirming accurate positioning. Local anesthesia (2% lidocaine) is applied. Lesions are performed at 85°C for 90 seconds per site. The radiofrequency generator used is CE-marked for pain procedures. The study evaluates a novel targeting protocol, not the safety or effectiveness of the device itself. No fluoroscopy is used. The procedure is performed once. Participants are followed for two years to assess outcomes.

Trial Locations (2)

8000-386

RECRUITING

Serviço de Medicina Física e de Reabilitação - Hospital de Faro - Unidade Local de Saúde do Algarve, Faro

1449-005

NOT_YET_RECRUITING

Serviço de Medicina Física e de Reabilitação - Hospital de São Francisco Xavier - Unidade Local de Saúde de Lisboa Ocidental, Lisbon

All Listed Sponsors
lead

Centro Hospitalar Universitario do Algarve

OTHER