Neoadjuvant Radiochemotherapy Combined With QL1706 for Low Rectal Cancer

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

May 20, 2025

Primary Completion Date

March 1, 2028

Study Completion Date

March 1, 2035

Conditions
Rectal Cancer
Interventions
COMBINATION_PRODUCT

SCRT+Capoex+QL706

Using a short-course radiotherapy treatment protocol, the primary tumor and high-risk areas were irradiated with a tumor dose of 25 Gy (5 Gy/treatment × 5 treatments); 2 weeks of rest after the end of radiotherapy were followed by 4 cycles of Capoex combined with QL706.

COMBINATION_PRODUCT

LCRT+Capoex+QL706

Using a long course radiotherapy treatment protocol, the primary tumor and high-risk areas were irradiated with a tumor dose of 50 Gy (2 Gy/treatment x 25 treatments); a 2-week break at the end of radiotherapy was followed by 4 cycles of Capoex combined with QL706.

All Listed Sponsors
lead

Changhai Hospital

OTHER