Comparison of Elranatamab and Lenalidomide Versus Daratumumab and Lenalidomide as Post-transplant Maintenance Therapy in Patients With Newly Diagnosed Myeloma (ElMMA)

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

176

Participants

Timeline

Start Date

May 1, 2025

Primary Completion Date

November 30, 2030

Study Completion Date

November 30, 2031

Conditions
Multiple Myeloma
Interventions
DRUG

Elranatamab

"Each injection may be up to 2 mL in volume; however, if the maximum volume allowed per institution's policy is lower than 2 mL, the number of injections may be increased to accommodate this difference in volume and ensure the correct dose is delivered. Elranatamab should be administered to the abdomen, with preference given to the lower quadrants when possible.~Each participant may receive study intervention for a maximum of 24 cycles."

DRUG

Daratumumab

1800 mg will be administrated every cycles

DRUG

Lenalidomide

Daily administarted during 21 days, at each cycle

Trial Locations (36)

Unknown

CHU Angers, Angers

CH Côte Basque, Bayonne

CHU Besançon, Besançon

CHU Caen, Caen

Hôpital d'Instruction des Armées Percy, Clamart

CHU Clermont- Ferrand - Hôpital ESTAING, Clermont-Ferrand

Hôpital Henri Mondor, Créteil

CHRU Dijon, Dijon

Institut de cancérologie de Bourgogne, Dijon

Hôpital Annecy Genevois, Épagny

CHD Vendée, La Roche-sur-Yon

CH Le Mans - Centre de cancérologie de la Sarthe, Le Mans

CH de Libourne, Libourne

CHU Limoges, Limoges

Groupement Hospitalier Bretagne Sud, Lorient

Centre Léon BERARD, Lyon

IPC Marseille, Marseille

CHRU Nancy, Nancy

CHU Nantes, Nantes

CHU de Nice - Hôpital l'Archet 1, Nice

CHU de Nîmes - Institut de Cancérologie du Gard, Nîmes

Hopital St Louis, Paris

Hôpital Cochin, Paris

Hôpital Necker, Paris

Hôpital St Antoine, Paris

CH Saint-Jean, Perpignan

CHRU - Hôpital du Haut Lévêque, Pessac

CH Périgueux, Périgueux

CHU de Poitiers, Poitiers

CH Cornouaille Quimper, Quimper

CH de Saint Nazaire, Saint-Nazaire

ICANS, Strasbourg

CH Tarbes-Lourdes, Tarbes

CHU Toulouse, Toulouse

CHRU Bretonneau, Tours

CH Bretagne Atlantique, Vannes

All Listed Sponsors
lead

Nantes University Hospital

OTHER