SCAN Electrical Stimulation for Parkinson's Disease

"* Stage 1: iTBS Intervention (14 days) and Washout Period (3-6 months)~ * All enrolled participants undergo:~ * Baseline clinical assessments~ * Structural and functional MRI with pBFS mapping~ * Resting motor threshold determination~ * Daily iTBS sessions targeting individualized SCAN coordinates:~ * Treatment duration: 14 consecutive days~ * Post-intervention evaluation at Day 14-21~ * Mandatory observation window:~ * No neuromodulation therapies permitted~ * Stable PD medication regimen maintained~ * Monthly safety monitoring~* Stage 2: Surgical Intervention and Follow-up (12 months)~ * Surgical Procedure:~ * Epidural electrode implantation~ * 7-day externalized stimulation testing~ * Pulse generator internalization~ * Chronic Stimulation Stage:~ * Parameter optimization visits~ * Scheduled follow-ups at Months 1, 3, 6, 9, 12"