186
Participants
Start Date
September 15, 2025
Primary Completion Date
June 30, 2028
Study Completion Date
December 31, 2028
transcutaneous auricular vagus nerve stimulation device
Place the stimulation device on the left auricle and set the stimulation parameters according to the following conditions: a. Waveform: biphase, square wave; b. Wave width: 200 μs; c. Frequency: Alternating between low frequency (4 Hz for 4 s), high frequency (40 Hz for 8 s), and a 4 s pause; d. Intensity: The maximum intensity that induces the strongest sensation the individual can tolerate without causing pain, usually 1.5-3.5 mA; e. Treatment duration: Each treatment lasted 30 minutes, twice daily (8:00, 16:00) for 10 days.
Sham device
The sham taVNS group received the same parameters with a current intensity of 0.06 mA.
RECRUITING
Beijing Tiantan Hospital, Capital Medical University, Beijing
Beijing Tiantan Hospital
OTHER