Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

April 5, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2029

Conditions
Mild Spinal Tuberculosis
Interventions
DRUG

Rifampin

Rifampin: once daily, 600 mg.

DRUG

Isoniazid

Isoniazid: once daily, 300 mg.

DRUG

Rifapentine (RPT)

Rifapentine: once daily with dosage adjusted based on body weight: 750 mg for ≤41.2 kg, 900 mg for \>41.3-48.7 kg, 1050 mg for \> 48.8-56.2 kg, 1200 mg for ≥ 56.3 kg.

DRUG

Moxifloxacin

Moxifloxacin: once daily, 400 mg.

DRUG

Pyrazinamide

Pyrazinamide: once daily with dosage adjusted based on body weight: 1000 mg for \< 55 kg, 1500 mg for ≥ 55-75 kg, and 2000 mg for \>75 kg.

DRUG

Ethambutol

Ethambutol: once daily with dosage adjusted based on body weight: 800 mg for \< 55 kg, 1200 mg for ≥ 55-75 kg, and 1600 mg for \> 75 kg.

Trial Locations (1)

Unknown

Shandong Public Health Clinical Center, Jinan

All Listed Sponsors
collaborator

Shandong Public Health Clinical Center

OTHER_GOV

lead

Shandong University

OTHER