MT027 in Patients With Advanced Peritoneal Malignancies or Abdominal Metastatic Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

May 12, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

December 31, 2028

Conditions
B7-H3-positive Advanced Malignant Solid Tumors Advanced Primary Peritoneal Tumors or Secondary Abdominal Metastatic Malignant Solid Tumors
Interventions
BIOLOGICAL

MT027 CAR-T cells

"Prior to MT027 cell infusion, lymphodepleting chemotherapy with fludarabine and cyclophosphamide was administered.~Dose Group 1: 1×10⁷ cells per administration; Dose Group 1: 3×10⁷ cells per administration; Dose Group 1: 6×10⁷ cells per administration; Based on the data obtained, adjustments to the specific number of cells in the established dosage groups and/or the addition of dosage groups may be made after discussion between the collaborators and researchers. A dose reduction titration may also be conducted based on the completed dosage groups."

Trial Locations (1)

Unknown

RECRUITING

The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

All Listed Sponsors
lead

Zhejiang University

OTHER

NCT06912152 - MT027 in Patients With Advanced Peritoneal Malignancies or Abdominal Metastatic Solid Tumors | Biotech Hunter | Biotech Hunter