NCT06910761 - Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 24, 2025

Primary Completion Date

October 2, 2028

Study Completion Date

October 2, 2028

Conditions

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell CarcinomaMetastatic Malignant Neoplasm in the LeptomeningesStage IV Lung Cancer AJCC v8

Interventions

PROCEDURE

Biospecimen Collection

Undergo blood and CSF sample collection

RADIATION

Craniospinal Irradiation

Undergo photon-VMAT-CSI

OTHER

Electronic Health Record Review

Ancillary studies

PROCEDURE

Lumbar Puncture

Undergo LP

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Ommaya Reservoir Tap

Undergo Ommaya reservoir tap

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Volume Modulated Arc Therapy

Undergo photon-VMAT-CSI

Trial Locations (2)

91010

RECRUITING

City of Hope Medical Center, Duarte

92618

RECRUITING

City of Hope at Irvine Lennar, Irvine

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER