Clinical Trial of CD5-targeted CAR-NK Therapy for Relapse/Refractory T-Cell Hematologic Malignancies

PHASE1RecruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

March 27, 2025

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2028

Conditions
T-ALL/Lymphoma
Interventions
BIOLOGICAL

Anti-CD5 CAR NK cells

Each patient will initially receive a single infusion of CAR-NK cells on Day 0. If a suboptimal response is observed after the first infusion (assessed by Day 28) and the safety profile remains acceptable, a second infusion may be administered as a remedial dose after Day 28. CAR-NK cells need to be controlled within 70 minutes from thawing to infusion completion.

Trial Locations (1)

430030

RECRUITING

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan

All Listed Sponsors
lead

Chongqing Precision Biotech Co., Ltd

INDUSTRY